Triple-Negative Breast Cancer Resource Library

National Comprehensive Cancer Network (NCCN)
Access current clinical practice guidelines for breast cancer.

Chemotherapy and Targeted Therapy for Patients with Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer That Is Either Endocrine-Pretreated or Hormone Receptor-Negative: ASCO Guideline Rapid Recommendation Update
This article provides updated recommendations of the ASCO guideline on chemotherapy and targeted therapy for patients with human epidermal growth factor receptor 2-negative metastatic breast cancer that is either endocrine pretreated or hormone receptor negative.

Bridging the Gap Between Clinical Practice and Treatment Disparities in Triple-Negative Breast Cancer: A Focus on Interventions Within Pharmacy Practice
This on-demand PTCE webinar for pharmacists provides tools and resources to identify socioeconomic factors, such as lack of insurance or access to health care, that may adversely impact patients with triple-negiative breast cancer (TNBC). The activity also includes a social worker perspective to add insight into health care disparities and other challenges affecting patients with TNBC.

Disparities in Cancer Care
Hear about the challenges and limitations disparate populations face when it comes to care access and  strategies for implementing interventions to help patients get the treatment they need.

Emerging Evidence in Triple-Negative Breast Cancer
This training for physicians, nurse practicioners, physican assitants, and nurses specializing in breast or medical oncology, discusses current, new, and emerging therapies for TNBC, managing adverse events, and evidence-based treatment decision-making for patients with advanced or metastatic disease. Note that CE credits for this activity are no longer available.

Evidence-Based Decision-Making in Advanced Triple-Negative Breast Cancer
This tool outlines the current treatment landscape and guideline recommendations for recurrent, unresectable, or metastatic TNBC.

Expanded Treatment Options in Metastatic Triple-Negative Breast Cancer
This training covers how immunotherapies, PARP inhibitors, and antibody-drug conjugates are improving outcomes for patients with metastatic TNBC.

In Pursuit of Equity: Diversity in Clinical Research Participation
To ensure equal access to quality cancer care for all, clinical trials must be made more accessible to underserved patient populations. This webinar by the Association of Community Cancer Centers details strategies to improve clinical trial accrual for racial and ethnic minorities, as well as other at-risk groups. Speakers also discuss successful solutions for working with community organizations to enhance interest and enrollment in clinical research.

Managing Adverse Events With Novel TNBC Treatments
This resource outlines how to effectively manage adverse events associated with novel TNBC therapies.

Metastatic Breast Cancer: Effective Principles and Practices in Patient Support
This publication includes a communication process map that integrates 6 effective principles into the care continuum, helping to reframe and improve the conversation between providers and patients, and examples of how cancer program members are putting these principles into action to delivery holistic, patient-centered care.

Patient Assistance and Reimbursement Guide Overview
The Digital Patient Assistance and Reimbursement Guide helps health care providers and patients find the most up-to-date information on the anticancer medication assistance and reimbursement programs that are available to help alleviate the financial burden of cancer treatment.

Practical Solutions to Better Engage Cancer Professionals With Communities of Color
This webinar by the Association of Community Cancer Centers provides a panel discussion and overview of currently available data on cancer care disparities, a discussion on the needs of disadvantaged populations, and practical solutions and methods for implementing bias training, and bi-directionally engaging your cancer program or practice with local community representatives.

Quality Improvement in Breast Cancer Testing: Highlights From ACCC Member Programs
This course highlights quality improvement projects focused on enhancing the quality of care for patients with breast cancer, including projects that support increasing the rates of guideline-concordant BRCA testing for this patient population.

Sacituzumab Govitecan (SG) versus Treatment of Physician’s Choice in Patients With Previously Treated, Metastatic Triple-Negative Breast Cancer: Results From the Phase 3 ASCENT Study
This presentation from the American Society of Clinical Oncology’s 2022 Annual Meeting reveals data on efficacy, including overall survival, safety, and quality of life for patents with metastatic TNBC treated with sacituzumab govitecan in the phase 3 ASCENT study (NCT02574455).

Targeted Therapies for Triple-Negative Breast Cancer
This panel training from Medscape summarizes the emergence of several important therapies for TNBC. A free account is required to access the training.

The Just ASK Increasing Diversity in Cancer Clinical Research: An ACCC-ASCO Training Program
This training program, adapted from a course developed at Duke University, is an online implicit bias training program intended for all members of the cancer research team. A series of interactive modules outline key concepts such as diversity, equity, and health disparities, as well as the role of implicit bias in clinical trial selection. Vignettes provide real-world examples of implicit bias from the perspective of community-based cancer programs and guidance for mitigating disparities in cancer research settings.

The TNBC Treatment Journey
This resource covers the various stages of TNBC and common treatments.

TNBC Discussion Guide: Questions to Ask Your Health Care Team
This resource provides a list of questions for patients to ask their care team after a diagnosis of TNBC.

TNBC on 1 Page
This 1-page resource for patients covers the basics of TNBC, questions to ask while preparing for treatment, and tips for finding emotional support.

Together, Equitable, Accessible, Meaningful (TEAM) Training
This training, from the George Washington University Cancer Center, aims to improve health equity by supporting organizational changes at the systems level. The training will help organizations implement quality improvements to advance equitable, accessible, and patient-centered cancer care through improved patient-provider communication, cultural sensitivity, shared decision-making and attention to health literacy.

Transforming Triple-Negative Breast Cancer Care in Community Oncology Practices
This resource summarizes a training on how to align treatment decision-making with the latest evidence and guideline recommendations for advanced/metastatic TNBC.

Transforming Triple-Negative Breast Cancer Care in Community Oncology Practices
This training for breast/medical oncologists, nurse practicioners, physican assitants, and nurses working within community, academic, and system practices, reviews insights from a TNBC quality improvement initiative instituted at community oncology practices across the nation. It also evaluates the latest clinical evidence and patient management approaches in TNBC to enhance evidence-based, patient-centered care.

Uncovering TNBC: Managing TNBC Risk
This resource discusses risk factors for TNBC, particularly in Black populations.

Cancer Support Community
This resources provides information for patients and caregivers including  free support groups, online community, educational resources, and toll-free helpline.

CancerCare
CancerCare provides free, professional support services for people affected by breast cancer, as well as breast cancer information and additional resources.

Caregiving for Your Loved One With Triple-Negative Breast Cancer
This webpage provides information to support caregivers of patients facing a TNBC diagnosis.

For the Breast of Us: Breast Cancer Baddie Directory
This searchable database helps to connect minority patients affected by TNBC.

Living Beyond Breast Cancer: About Triple-Negative Breast Cancer
This webpage discusses basic information about TNBC, including staging, treatment options, survivorship, and support programs for those living with TNBC.

Living With Metastatic TNBC
This resource from the Triple Negative Breast Cancer Foundation discusses treatment options, and palliative and supportive care options for people who have been diagnosed with metastatic TNBC.

Living With TNBC: Newly Diagnosed
This resource from the Triple Negative Breast Cancer Foundation discusses action steps for people who are newly diagnosed with TNBC.

Living With TNBC: Survivorship
This resource from the Triple Negative Breast Cancer Foundation discusses the importance of survivorship care plans and ongoing monitoring for TNBC survivors.

SHARE
Access free breast cancer support groups, helpline, online community, and more.

Sisters Network Breast Cancer Assistance Program
This national financial assistance program from the Sisters Network, a national African American breast cancer survivorship organization, provides financial assistance to those  in active treatment. The program also has an early-detection component providing mammograms for underserved and uninsured patients.

Sisters Network, Inc
Sisters Network is a national African American breast cancer survivorship organization.

Susan G. Komen
Access a treatment assistance program, helpline, online community, and other resources. Susan G. Komen’s mission “is to save lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer.”

Tigerlily Foundation
The Tigerlily Foundation provides education, awareness, empowerment, advocacy, and support to those with breast cancer during and after treatment.

Triple-Negative Breast Cancer Caregivers Support Group
This online support group from CancerCare provides caregiver support and an opportunity to connect with others facing TNBC.

Triple Negative Breast Cancer Foundation Clinical Trial Matching Service
This resource from the Triple Negative Breast Cancer Foundation assists patients in making informed treatment decisions, which may include clinical trials.

Triple-Negative Breast Cancer Support Group
This online support group from CancerCare provides patient support and an opportunity to connect with others coping with triple negative breast cancer.

Triple-Negative Breast Cancer: Coping With the Fear of Recurrence
This podcast from CancerCare covers topics related to TNBC recurrence.

What Does the African American Community Need to Know About Triple-Negative Breast Cancer?
This video from Cancer Support Community provides a virtual community navigator to explain what minority communities need to know about TNBC.

What Makes Triple-Negative Breast Cancer Aggressive?
This video from SHARE covers some of the basic facts about TNBC, including what it is and why it is considered aggressive. SHARE is a national non-profit dedicated to serving people of all races and cultures, backgrounds, and identities.

Breast Cancer in the Central Nervous System: Multidisciplinary Considerations and Management
Patients with metastatic breast cancer, particularly those with HER2-positive or Triple-Negative Breast Cancer (TNBC), are at the highest risk of developing brain metastases in the parenchyma. Although no systemic therapies have received regulatory approval specifically for treating brain metastases in breast cancer, several treatment regimens have shown promise in prospective studies. Furthermore, ongoing clinical trials are exploring various approaches to address this challenging aspect of breast cancer management.

Breastfeeding and Breast Cancer Risk Reduction: Implications for Black Mothers
This journal article discusses breast cancer disparities in the context of breastfeeding and the implications for black mothers.

Breastfeeding and Triple-Negative Breast Cancer: Potential Implications for Racial/Ethnic Disparities
This journal article identifies modifiable risk factors contributing to the unequal burden of TNBC, including racial/ethnic disparities in breastfeeding rates.

Disparities in Breast Cancer Associated With African American Identity
Several disparities exist in the treatment and outcomes of minorities  diagnosed with breast cancer. The relevant issues are multifactorial in etiology and will require collective efforts of health care system policy experts, multidisciplinary oncology providers, and researchers to address the factors that are modifiable and/or potentially suitable for targeted interventions.

Insights Into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment
This journal article reviews efforts to classify TNBC based on the comprehensive profiling of tumors for cellular composition and molecular features. Technological advances allow for tumor characterization at ever-increasing depth, generating data that, if integrated with clinical-pathologic features, may help improve risk stratification of patients, guide treatment decisions and surveillance, and help identify new targets for drug development.

Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge
This review outlines the role of crucial pathways in TNBC survival following chemotherapy treatment and highlights the importance of using combinatorial drug strategies and incorporating biomarkers in clinical studies.

Metabolic Reprogramming in Triple-Negative Breast Cancer
This journal article discusses how TNBC cells reprogram their metabolic phenotype and that of stromal cells in the microenvironment to survive under nutrient-poor conditions. It also focuses on the role of metabolic adaptation in mediating metastasis and chemoresistance of TNBC tumors.

Racial Disparities in Triple-Negative Breast Cancer: A Review of the Role of Biologic and Nonbiologic Factors
This review discusses the interactions by which nonbiologic and biologic factors intersect to drive the initiation and development of the disparities resulting in the aggressive TNBC subtypes more likely in African American populations.

Racial Disparities in Triple-Negative Breast Cancer: Toward a Causal Architecture Approach
This journal article discusses the use of the race, income, and race/income versions of the neighborhood Index of Concentration at the Extremes (ICE) metrics to identify census tracts with higher odds of TNBC relative to other forms of invasive breast cancer. The use of ICE metrics can facilitate the monitoring of cancer inequities and advance the study of racial disparities in breast cancer.

Role of Immunotherapy in Triple-Negative Breast Cancer
This review presents immune checkpoint inhibitors monotherapy response rates and discusses combination strategies with chemotherapy, targeted therapies, and novel immunotherapies. It concludes with a summary of immunotherapy biomarkers in TNBC.

Sacituzumab Govitecan as Second-Line Treatment for Metastatic Triple-Negative Breast Cancer—Phase 3 ASCENT Study Subanalysis
This ASCENT subanalysis provides information about sacituzumab govitecan as second-line treatment for metastatic TNBC with a specific focus on a subgroup of patients without known baseline brain metastases. Results found sacituzumab govitecan improved survival over conventional chemotherapy for patients with TNBC.

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer
In patients with challenging metastatic triple-negative breast cancer (TNBC), the prognosis is often poor. To tackle this, a novel antibody-drug conjugate, sacituzumab govitecan, has been developed. This conjugate combines an antibody targeting the Trop-2 antigen, commonly found in breast cancer, with SN-38, a potent topoisomerase I inhibitor, using a proprietary linker. This summary pertains to a pivotal phase 3 clinical trial comparing sacituzumab govitecan to healthcare provider-selected single-agent chemotherapy for patients dealing with relapsed or refractory metastatic TNBC

Safety Analyses from the Phase 3 ASCENT Trial of Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer
This ASCENT safety analysis includes the impact of age and UGT1A1 polymorphisms, which hinder SN-38 detoxification. Sacituzumab govitecan demonstrated a manageable safety profile in patients with metastatic TNBC, including those aged older than 65 years.

Significant Clinical Activity of Olaparib in a Somatic BRCA1-Mutated Triple-Negative Breast Cancer With Brain Metastasis
This case report describes a heavily pretreated patient with TNBC brain metastasis and a BRCA1 somatic mutation with a remarkable and durable response to PARP inhibitor therapy. This is the first case report to demonstrate disease response to PARP inhibition in a TNBC without a germline BRCA1 or BRCA2 mutation.

Suboptimal Therapy Following Breast Conserving Surgery in Triple-Negative and HER2-Positive Breast Cancer Patients
This journal article assesses potential disparities in guideline-concordant care delivery among individuals with early-stage triple-negative and HER2-positive breast cancer treated with breast conserving therapy.